Holmes Run
General data
- Name: Holmes Run
- Water system: Potomac River
- Water type: Stream
- Progression: Cameron Run -> Hunting Creek -> Potomac River -> Chesapeake Bay -> Atlantic Ocean -> Planet Earth
- Climates: Continental
- Continents: North America
- Countries: United States of America
Holmes Run is a stream in the Cameron Run Watershed in Northern Virginia. It runs through Fairfax County and the City of Alexandria. It is a first-order tributary of the Potomac River.
Its headwater is near the junction of I-495 and I-66. It crosses the region in a southeasterly direction for ten and a half miles until it merges with Backlick Run to form Cameron Run. Cameron Run becomes Hunting Creek and empties into the Potomac River just south of the Woodrow Wilson Bridge.