Stono River
General data
- Name: Stono River
- Water system: Atlantic Ocean
- Water type: River
- Progression: Atlantic Ocean -> Planet Earth
- Climates: Subtropical
- Continents: North America
- Countries: United States of America
The Stono River or Creek is a tidal river (channel) in southeast South Carolina, located southwest of Charleston. The channel runs southwest to northeast between the mainland and Wadmalaw Island and Johns Island, from north Edisto River between Johns (West) and James (East) Islands. The Intracoastal Waterway runs through southwest–northeast section of the channel.