St. Sebastian River
General data
- Name: St. Sebastian River
- Water system: Atlantic Ocean
- Water type: River
- Progression: Indian River (Florida) -> Indian River Lagoon (Florida) -> Atlantic Ocean -> Planet Earth
- Climates: Subtropical
- Continents: North America
- Countries: United States of America
The Saint Sebastian River is a river in the U.S. state of Florida, a tributary of the Indian River west and north of the city of Sebastian.