Murderkill River
General data
- Name: Murderkill River
- Water system: Delaware Bay
- Water type: River
- Progression: Delaware Bay -> Atlantic Ocean -> Planet Earth
- Climates: Temperate
- Continents: North America
- Countries: United States of America
The Murderkill River is a river flowing to Delaware Bay in central Delaware in the United States. It is approximately 21.7 miles (34.9 km) long and drains an area of 106 square miles (270 km2) on the Atlantic Coastal Plain.